• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Agmatine sulfate salt

CAS No. 2482-00-0

Agmatine sulfate salt ( Agmatine sulfate )

产品货号. M19581 CAS No. 2482-00-0

硫酸胍丁胺是精氨酸的生物活性代谢物。它对多个分子靶点发挥调节作用,例如神经递质系统、离子通道和一氧化氮合成。它是咪唑啉受体的内源性激动剂和 NO 合酶抑制剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG ¥332 有现货
1G ¥535 有现货

生物学信息

  • 产品名称
    Agmatine sulfate salt
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    硫酸胍丁胺是精氨酸的生物活性代谢物。它对多个分子靶点发挥调节作用,例如神经递质系统、离子通道和一氧化氮合成。它是咪唑啉受体的内源性激动剂和 NO 合酶抑制剂。
  • 产品描述
    Agmatine sulfate is a bioactive metabolite of the arginine amino acid. It exerts modulatory action at multiple molecular targets such as neurotransmitter systems ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
  • 体外实验
    Agmatine binds to alpha 2-adrenergic and imidazoline receptors and stimulates release of catecholamines from adrenal chromaffin cells. Its biosynthetic enzyme, arginine decarboxylase, is present in brain. Agmatine, locally synthesized, is an endogenous agonist at imidazoline receptors, a noncatecholamine ligand at alpha 2-adrenergic receptors and may act as a neurotransmitter. Agmatine is synthesized in the brain, stored in synaptic vesicles in regionally selective neurons, accumulated by uptake, released by depolarization, and inactivated by agmatinase. Agmatine inhibits nitric oxide synthase, and induces the release of some peptide hormones. Agmatine, 4-(aminobutyl)guanidine, is produced by decarboxylation of L-arginine by the enzyme arginine decarboxylase. Agmatine is a competitive inhibitor of all NOS isoenzymes but not an NO precursor. Ki values are approximately 660 μM (NOS I), 220 μM (NOS II) and 7.5 mM (NOS III). Agmatine stimulates nitrite production three-fold above basal nitrite formation by endothelial cells. Agmatine displaces [3H]-idazoxan from endothelial cellmembranes and is found to induce transients in the cytosolic calcium of endothelial cells. The transients could be downregulated by repeated exposure to agmatine but are not affected by pretreatment with norepinephrine.
  • 体内实验
    Agmatine produces an antidepressant-like effect when assessed in the forced swimming test and in the tail suspension test in mice (dose range 0.01-50 mg/kg, i.p.), without accompanying changes in ambulation in an open-field. In ischemic stroke, agmatine protects the blood-brain barrier, which can be monitored in vivo by quantification of permeability by using dynamic contrast-enhanced MR imaging. Agmatine substantially augments the antidepressant-like effect of MK-801, reinforcing the notion that this compound modulates NMDA receptor activation.
  • 同义词
    Agmatine sulfate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    imidazoline receptor| NO synthase
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2482-00-0
  • 分子量
    228.27
  • 分子式
    C5H16N4O4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    H2O:100 mg/mL (438.08 mM)
  • SMILES
    OS(O)(=O)=O.NCCCCNC(N)=N
  • 化学全称
    2-(4-Aminobutyl)guanidine sufate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Li G et al. Agmatine: an endogenous clonidine-displacing substance in the brain. Science. 1994 Feb 18;263(5149):966-9.
产品手册
关联产品
  • 3-O-p-Coumaroylquini...

    3-Op-Coumaroylquinic Acid 是羟基肉桂酸衍生物,是从 70% 山楂甲醇提取物 (Crataegi folium cum flore) 中分离出来的。

  • URB602

    URB602是一种特异性单酰基甘油脂肪酶(MGL)抑制剂,通过非竞争性机制抑制大鼠脑MGL(IC50:28±4 μM)。

  • Pipemidic acid

    Pipemidic scid 是一种新型抗菌剂,对铜绿假单胞菌具有活性。